Expression of Cyclin D1 in Normal, Hyperplastic and Neoplastic Endometrium

Background: Overexpression of Cyclin D1, a positive cell cycle regulator, may lead to uncontrolled cell proliferation. Aim: The present study was undertaken to examine the expression profile of Cyclin D1 in normal, hyperplastic and neoplastic endometrium and to evaluate the possibility of its role in the genesis of endometrial neoplastic and preneoplastic lesions. Settings and Design: A cross sectional study conducted during a 1 year period in a tertiary referral centre. Materials and Methods: We evaluated and compared the expression profile of Cyclin D1 in 50 endometrial samplings that were diagnosed as simple hyperplasia without atypia (n=12), complex hyperplasia without atypia (n=7), complex hyperplasia with atypia (n=4), endometrial carcinoma (n=7) and proliferative (n=10) and secretory (n=10) endometrium. Results: An increasing gradient of Cyclin D1 expression was noted in endometrial glands from normal endometrium to hyperplasia to carcinoma Conclusion: Cyclin D1 overexpression is an early event in endometrial carcinogenesis.